{"id":30899,"date":"2025-09-24T19:34:05","date_gmt":"2025-09-24T23:34:05","guid":{"rendered":"https:\/\/valuecare.wpgamma.com\/?p=30899"},"modified":"2025-09-24T19:34:05","modified_gmt":"2025-09-24T23:34:05","slug":"green-tea-extract-may-help-prevent-type-2-diabetes-through-improved-glucose-tolerance","status":"publish","type":"post","link":"https:\/\/valuecare.wpgamma.com\/index.php\/2025\/09\/24\/green-tea-extract-may-help-prevent-type-2-diabetes-through-improved-glucose-tolerance\/","title":{"rendered":"Green tea extract may help prevent type-2 diabetes through improved glucose tolerance"},"content":{"rendered":"
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(NewsTarget) A new study by DSM Nutritional Products shows that epigallocatechin gallate, commonly known as EGCG, improves glucose tolerance in\u00a0diabetic<\/a>\u00a0rodents and could be a positive addition to dietary prevention of type 2\u00a0diabetes<\/a>, if the results can be applied to humans.<\/p>\n

\u201cTo our knowledge, we provide the first evidence that EGCG consumed in the diet exerts potent anti-diabetic<\/a>\u00a0activity in vivo in a dose-dependent manner,\u201d wrote lead author Swen Wolfram of DSM in the Journal of Nutrition.<\/p>\n

The study looked at 37 male mice who were severely\u00a0diabetic<\/a>, and divided them into four groups. The rats were fed 2.5, 5 or 10 grams of EGCG per kilogram of diet, or a placebo, for seven weeks.<\/p>\n

At the five-week mark, the researchers tested oral glucose tolerance and found that glucose levels reduced by 23, 35 and 48 percent in the 2.5-, 5- and 10-gram categories respectively. At six weeks into the study, the scientists tested\u00a0insulin<\/a>\u00a0tolerance and blood samples were taken at the end of the test to analyze glucose, free\u00a0fatty acids<\/a>\u00a0and triacylglyceride levels. All improved on a dose-dependent basis.<\/p>\n

The researchers also studied the effects of 5 grams of EGCG per kilogram of diet over a 10-week period on mildly diabetic rats and found that glucose tolerance,\u00a0blood glucose levels<\/a>, and free fatty acid plasma concentrations all improved. Analysis of rat liver cells revealed that EGCG down-regulated the genes involved in gluconeogenesis and the synthesis of\u00a0fatty acids<\/a>, triacylglycerol and cholesterol.<\/p>\n

\u201cOur data suggest that supplementation with EGCG could potentially improve glucose tolerance in humans with type-2\u00a0diabetes<\/a>\u00a0mellitus,\u201d concluded the researchers. \u201cThis hypothesis should now be investigated in randomized placebo-controlled trials.\u201d Wolfram said that DSM intends to begin such trials soon.<\/p>\n

In the United States, more than 20 million people suffer from\u00a0diabetes<\/a>\u00a0\u2014 about 7 percent of the population \u2014 and about 19 million people in the European Union are so afflicted \u2014 about 4 percent of the population. The cost of treating the disease is about $132 billion, according to the American Diabetes Association.<\/p>\n

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